
This 25-year-old man has got round, brown, scaly patches over his chest. It has been diagnosed as a fungal infection but has not responded to oral terbinafine for two weeks.
The superficial brown scaly patches are highly suggestive of a yeast infection called pityriasis versicolor — it is due to a yeast called Malassezia and not a dermatophyte fungus.
The best way to confirm the diagnosis is by taking skin scrapings. The yeast pseudohyphae and spores are said to resemble spaghetti and meatballs when looked at using a potassium hydroxide wet preparation on microscopy.
Unfortunately, it does not respond to oral terbinafine, which is highly active against dermatophyte fungi but not the causative yeast. It can be treated by using topical azole shampoos or creams, or a short course of oral itraconazole.
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26 August 26
Sam
Terbinafine can be very effective against cutaneous dermatophytes ,but I think two weeks is rather too short for an effective therapeutic outcome . Perhaps ,4-6weeks could be allowed with regular LET'S monitoring . I would also combine a topical clotrimazole shampoo or even terbinafine cream for two weeks .
26 August 26
Viktoriia
Thank you for this excellent case. A very useful reminder of the importance of KOH microscopy in differentiating pityriasis versicolor from dermatophyte infection, especially when the clinical appearance can be misleading. Very practical and memorable.
26 August 26
Sami
Great info
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