Fox-Fordyce disease is a rare skin disorder in which apocrine sweat is trapped with resultant inflammation. It is also called apocrine miliaria, apocrine duct occlusion, and sweat retention disease.
Who gets Fox-Fordyce disease?
Fox-Fordyce disease mainly affects post-pubertal women between the ages of 13 and 35 years. Children and males are sometimes affected.
What causes Fox-Fordyce disease?
The cause of Fox-Fordyce disease is unknown. Apocrine sweat becomes trapped by a keratotic plug in the hairfollicle. The apocrine sweat ducts within the epidermis rupture and leak to cause inflammation and intense itch.
Factors identified as playing a part in the development of the condition include:
Emotional and hormonal influences
Alterations in sweat components
Laser hair removal.
What are the signs and symptoms of Fox-Fordyce disease?
Fox-Fordyce disease is characterised by itchy bumps around the hair follicles of the underarm area, pubic region, and around the nipples as apocrine sweat glands are found only in these areas.
Fox-Fordyce disease may result in very intense itch that disturbs sleep, but in some cases is asymptomatic. The condition frequently occurs under conditions of heat, humidity, friction, and stress.
Common clinical signs of Fox-Fordyce disease include:
Dome-shaped flesh-coloured to small reddish papules affecting almost every hair follicle in the area
Bilateral
Dark, thickened, dry skin as a consequence of scratching (lichenification)
Reduced or absent sweating in the affected area.
Fox-Fordyce disease of the axilla
Dermoscopy features of Fox-Fordyce disease
Folliculocentric papule
Multiple light brown to dark structureless areas, lack pigment network
Central hyperkeratotic plug in each papule
How is the diagnosis of Fox-Fordyce disease made?
Fox-Fordyce disease is usually diagnosed on the history and clinical appearance of the rash.
Skin biopsy may require serial sectioning to demonstrate the characteristic histology findings of:
Keratotic plug above the point where the apocrine duct joins the hair follicle
Spongiosis and vesicle formation in the follicularinfundibulum and epidermis
Mild to moderate perifollicularinfiltrate of neutrophils and chronicinflammatory cells
Xanthomatous foamy cells.
What is the treatment for Fox-Fordyce disease?
There is no cure for Fox-Fordyce disease. Treatments used with variable degrees of success include:
Fox-Fordyce disease may persist for many years. In some instances, it may clear up in pregnancy. In others, it may resolve at the menopause or continue to persist.
Bibliography
Miao C, Zhang H, Zhang M, Zhang X. Fox-Fordyce disease.An Bras Dermatol. 2018;93(1):161–2. doi:10.1590/abd1806-4841.20187348
Sammour R, Nasser S, Debahy N, El Habr C. Fox-Fordyce disease: an under-diagnosed adverse event of laser hair removal?. J Eur Acad Dermatol Venereol. 2016;30(9):1578–82. doi:10.1111/jdv.13680. PubMed
Singal A, Kaur I, Jakhar D. Fox-Fordyce disease: dermoscopic pperspective. Skin Appendage Disord. 2020;6(4):247–9. doi:10.1159/000508201. PubMed Central
